# Origin of Misfolding
> Local Misfolding 
> Vulnerable Sites
> Common Epitopes
> Generic Misfoldon 

# Therapeutics 
> Sequence Analysis
> Designing Conjugate Sequence 
> Aggregation Propensity
> Effective Aggregation Suppressor   

# Diagnosis
> Physicochemical Properties
> Clinical Observables 
> Universal Predictor
> Novel Deeleterious and Beneficial Mutants

# Forcefield Optimization
> Possible Combinations
> Polymer Dynamics
> Conformational Landscape Characterization
> Comparison with Experiments